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Total Periarticular Infiltration Vs Posterior Periarticular Infiltration Plus PENG Block for Hip Analgesia

RecruitingNAAges 18 Years - 80 YearsAllUniversity of Chile
NCT06075004 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In a recent study, direct periarticular local anesthetic infiltration (PAI) showed a greater incidence of early quadriceps weakness (33% at 3 hours and 13% at 6 hours) than pericapsular nerve group block (PENGB) in total hip arthroplasty (THA) but, in turn, demonstrated a statistically significant better pain control. Additionally, PENGB could not completely circumvent motor compromise either, particularly at 3 hours (20% incidence), probably secondary to an injectate migration towards the femoral nerve. Posteriorly to this publication, a cadaveric trial looking into the maximum effective volume that spared the femoral nerve resulted in 13.2 mL. This newer evidence led to the design of a strategy that combines both interventions, aiming to obtain the best of them and have a solid alternative for those cases where very early mobilization is pursued. Thus, it is hypothesized that posteri

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📋 Eligibility rules (as published)
Inclusion Criteria: * American Society of Anesthesiologists classification 1-3 * Body mass index between 20 and 35 (kg/m2) Exclusion Criteria: * Adults who are unable to give their own consent * Pre-existing neuropathy (assessed by history and physical examination) * Coagulopathy (assessed by history and physical examination and, if deemed clinically necessary, by blood work-up i.e. platelets ≤ 100, International Normalized Ratio ≥ 1.4 or prothrombin time ≥ 50) * Renal failure (assessed by history and physical examination and, if deemed clinically necessary, by blood work-up i.e. creatinine ≥ 100) * Hepatic failure (assessed by history and physical examination and, if deemed clinically necessary, by blood work-up i.e. transaminases ≥ 100) * Allergy to local anesthetics (LAs) or morphine * Pregnancy * Prior surgery in the inguinal area corresponding surgical side * Chronic pain syndromes requiring opioid intake at home
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What it tests

  • Periarticular Local Anesthetic Infiltration
  • Posterior Periarticular Local Anesthetic Infiltration plus Pericapsular Nerve Group Block
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Where

1 site
Hospital Clínico Universidad de Chile
Santiago, Chile
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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