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EMG-guided Botox Injection Versus Conventional Botox Injection in Gummy Smile Patients

RecruitingNAAges 18 Years - 50 YearsAllCairo University
NCT06075134 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to compare the effect of EMG-guided Botox injection with conventional Botox injection in Yonsei point, in patients with excessive gingival display. The main question it aims to answer is: • Does the use of electromyography (EMG) as a guide during Botox injection for patients with gummy smile has better effect than conventional injection in Yonsei point? Participants will be randomized in equal proportions between intervention and control groups. * Preoperative assessment of amount of gingival display, lip length (philtrum and vermilion length), and smile type. * For the intervention group, EMG readings will be done in Clinical Neurophysiology Department, Kasr Al-Ainy Hospital EMG-guided Botox injection (Intervention group). Conventional Botox injection in Yonsei point (Control group).

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients with excessive gingival display. * Patients with esthetic concerns. * Patients with mild to moderate VME (vertical maxillary excess). * Normal clinical crown dimensions. * Patients aged 18 to 50. * Systemically healthy patients. * Non-smokers. Exclusion Criteria: * Patients with severe VME (vertical maxillary excess). * Pregnant and breastfeeding women. * Patients with gingival inflammation and/or enlargement. * Inflammation or infection at the site of injection. * Patients with known allergy to any of the components of Botox (i.e., saline, human albumin, lactose and sodium succinate). * Patients using anticholinesterase or other agents affecting neuromuscular transmission. * Psychologically unstable patients or those who have unrealistic expectations and questionable motives. * Patients with neuromuscular disorders (e.g., myasthenia gravis, Eaton-Lambert syndrome).
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What it tests

  • Botox injection
  • EMG
  • Zinc Supplement
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Where

1 site
Faculty of Dentistry, Cairo University
Cairo, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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