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Impact of Confirmed Autoimmune Encephalitis on Brain Glucose Metabolism

RecruitingNAAges 18 Years - anyAllAssistance Publique - Hôpitaux de Paris
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In plain words

What the trial is, and whether it could suit you

Prospective cohort study evaluating FDG PET in 56 patients with confirmed autoimmune encephalitis - based on 2016 Graus criteria, and 2021 paraneoplastic neurological syndromes criteria - at the acute phase, before immunomodulating treatment, or within 10 days of treatment initiation.

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 years old * Newly diagnosed autoimmune encephalitis based on at least 1 of the 3 following criteria : 1. " Definite limbic autoimmune encephalitis " according to 2016 Graus et al. criteria 2. " Possible autoimmune encephalitis " according to 2016 Graus et al. criteria AND typical autoantibody detected in serum or CSF 3. " Probable or certain paraneoplastic neurological syndrome " according to Graus et al. 2021 criteria (excluding peripheral neurological syndromes) * Less than 6 months since first neurological symptoms imputable to autoimmune encephalitis * Affiliated or entitled to a social security system (except AME) * Obtaining free, written and informed consent (patient or legal representative or the close relative) Exclusion criteria * History of brain tumor, head trauma, infarction or cerebral hematoma likely to result in altered cerebral carbohydrate metabolism on PET * Patients who hae been on immunotherapy (corticosteroid bolus, IVIg, plasma exchange, endoxan, rituximab or other immunotherapy) fr more than 10 days * Pregnant or breast-feeding woman * Ventilated intubated patient * Absolute contraindication to MRI (Pacemaker, cochlear implant, etc.) * Presence of cognitive disorders incompatible with goog cooperation with the PET scan * Algic or agitated patient unable to remain immobile in supine position for 30 minutes * Deprived of liberty or under a protective measure (guardianship or curatorship) * Patient taking part in other interventional research involving radiopharmaceutical injections
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What it tests

  • FDG PET
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Where

1 site
Hospital Pitie Salpetriere
Paris, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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