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Vasopressor Impact on Brain Circulation, Organ Blood Flow and Tissue Oxygenation During Anesthesia

RecruitingPhase 2, Phase 3Ages 18 Years - 75 YearsAllUniversity of Aarhus
NCT06083948 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The optimal vasopressor for ensuring organ blood flow and tissue oxygen delivery during surgery remains undetermined. This study aim to compare the effects of noradrenaline vs. phenylephrine infusion on blood flow and oxygen delivery to the brain and various other organs in anesthetized neurosurgical patients.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Clinical diagnosis of supratentorial malignant or non-malignant brain tumors. Preferably 3 cm or larger( measured as the largest diameter in any plane on MRI). 2. Scheduled for elective supratentorial craniotomy. 3. Patients aged between 18 and 75 years. 4. American Society of Anesthesiologists status 1-3 Exclusion Criteria: 1. History of allergy or intolerance to one of the study medications. 2. Active treatment with monoamine oxidase inhibitors. 3. An American Society of Anesthesiologists (ASA)physical status IV-VI. 4. Pregnancy or breastfeeding. 5. Inability to provide written informed consent -
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What it tests

  • Noradrenalin
  • Phenylephrine
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Where

1 site
Aarhus University Hospital
Aarhus, Denmark
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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