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โ† Trials
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Cryospray Therapy for Benign Airway Stenosis

RecruitingPhase 1Ages 18 Years - anyAllVirginia Commonwealth University
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In plain words

What the trial is, and whether it could suit you

This is a clinical evaluation to assess the effectiveness of cryospray therapy used in addition to current standard of care endoscopic therapies in preventing short term recurrent airway stenosis with a multicentric outcome evaluation. The investigators hypothesize that the addition of SCT to standard endoscopic treatment of benign airway stenosis will result in decreased stenosis recurrence at 6 months as estimated by quantitative radiologic assessment of the stenotic volume.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Referral to interventional pulmonology or otorhinolaryngology or thoracic surgery for endoscopic management of suspected benign tracheal stenosis. * Significant tracheal stenosis defined by stenosis โ‰ฅ 50% of tracheal lumen assessed on chest CT or previous bronchoscopy * Able to provide informed consent. * Age \> 18 Exclusion Criteria: * Inability to provide informed consent * Pregnancy * Known or suspected malignant central airway stenosis * Patient has already been enrolled in this study. * Study subject has any disease or condition that interferes with safe completion of the study including: 1. Hypoxemia with need for supplemental oxygen โ‰ฅ 2L/min by nasal canula 2. Pneumothorax in the previous 12 months 3. Severe COPD (defined as a FEV1/FVC \< 70% and FEV1 \<30% predicted) and/or severe persistent asthma. 4. Hemodynamic instability with systolic blood pressure \<90 mmHg or heart rate \> 120 beats/min, unless deemed to be stable with these values by the attending physicians. 5. Compromised tissue where significant ulceration or mucosal break is evident in the ablation area or adjacent organs. 6. Significantly reduced tissue strength caused by prior procedure or pre-existing condition (e.g. PEG tube) 7. Significantly reduced elasticity of the ablation area (e.g. Marfan's Syndrome) * Prior complications with SCT (Spray cryotherapy) * Contraindication to rigid bronchoscopy * Significant tracheomalacia or alterations in cartilage integrity on CT (Computed Tomography) that would require stent placement or surgical referral. * Greater than 1 BCAS intervention, excluding cricotracheal (tracheal surgery) resection, within 6 months before enrollment. * Anatomical flow resistance (gas evacuation) where any procedure or anatomy proximal to the ablation site has significantly reduced or restricted the flow area of the lumen creating restriction where gas created from liquid nitrogen cannot adequately vent.
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What it tests

  • The truFreeze Spray Cryotherapy
  • Ballon dilation
  • Radial Incision
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Where

1 site
Virgnia Commonwealth University
Richmond, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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