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IMPRoving Outcomes in Vascular DisEase - Aortic Dissection

RecruitingNAAges 21 Years - anyAllDuke University
NCT06087029 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to determine whether an upfront invasive strategy of TEVAR plus medical therapy reduces the occurrence of a composite endpoint of all-cause death or major aortic complications compared to an upfront conservative strategy of medical therapy with surveillance for deterioration in patients with uncomplicated type B aortic dissection.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age \> 21 years 2. Patients with a Stanford type B aortic dissection not involving the aorta at or proximal to the innominate artery, without rupture and/or malperfusion syndrome (renal, mesenteric, or extremity) who are within 48 hours to 6 weeks after start of index admission for their type B dissection 3. Ability to provide written informed consent 4. Investigator believes anatomy is suitable for TEVAR Exclusion Criteria: 1. Ongoing systemic infection 2. Pregnant or planning to become pregnant in the next 3 months 3. Life expectancy related to non-aortic conditions \< 2 years 4. Unwilling or unable to comply with all study procedures 5. Known patient history of genetic aortopathy 6. Penetrating Aortic Ulcer without concomitant uTBAD 7. Intramural hematoma without concomitant uTBAD 8. Iatrogenic (traumatic) aortic dissection
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What it tests

  • TEVAR
  • Guideline directed medical therapy and surveillance of dissection
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Where

66 sites
University of Alabama at Birmingham
Birmingham, United States
Honorhealth
Phoenix, United States
University of Arkansas for Medical Sciences
Little Rock, United States
Memorial Care Long Beach Medical Center
Long Beach, United States
Keck Medical Center of USC
Los Angeles, United States
Kaiser Permanente San Francisco
Pleasanton, United States
University of California San Diego
San Diego, United States
University of California
San Francisco, United States

…and 58 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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