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Arsenic Trioxide Combined With Chemotherapy for the Treatment of p53-mutated Pediatric Cancer

RecruitingPhase 2Ages any - 18 YearsAllYang Li
NCT06088030 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

This prospective, single-arm, multi-center clinical trial aims to explore and evaluate the efficacy and safety of arsenic trioxide combined with chemotherapy for pediatric cancer with p53 mutation.

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. Pathological diagnosis basis of malignant tumor๏ผ› 2. Patients not more than 18 years old; 3. Patient has either germline or somatic p53 mutations, which was shown to be partially/completely restored to function by ATO in in vitro experiments (http://www.rescuep53.net); 4. There are measurable lesions; 5. Guardians agreed and signed informed consent. Exclusion Criteria: Patients with one or more critical organs failure such as heart, brain, kidney failure.
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What it tests

  • Arsenic trioxide
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Where

1 site
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Guangzhou, China
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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