Vagal Nerve Stimulation in Irritable Bowel Syndrome

Inclusion Criteria: * A diagnosis of IBS according to Rome IV criteria (3), as follows: * Recurrent abdominal pain, on average, at least 1 day per week in the last 3 months, associated with 2 or more of the following criteria: * Related to defecation. * Associated with a change in stool frequency. * Associated with a change in stool from (appearance). * Criteria fulfilled for the last 3 months with symptom onset at least 6 months prior to diagnosis. * Age between 18 and 75 years; * Ability to understand and speak the Dutch language. * Ability to understand how to utilize the ESM application. Exclusion Criteria: * A history of abdominal surgery, except for uncomplicated appendectomy, laparoscopic cholecystectomy and hysterectomy is present or otherwise based on the principal investigator's judgement. * Presence of metallic prostheses, pacemakers, metal clips on blood vessels, metal parts in the eye, an intrauterine device (with the exception of the Mirena IUD), metal braces, facial tattoos and/or metal objects. * History of major head trauma or head/brain surgery * History of claustrophobia * Pregnancy, lactation, intention to become pregnant during the study period * Students and employees of Maastricht University are not precluded from participation, unless they have a direct personal, professional or hierarchical position with regards to any of the study team members or their department. * If the subject has a cardiac arrhythmia, the attending physician will be consulted before participation.