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Microvascular Angina Intervention With Compound Danshen Dripping Pill (MAIDS)

RecruitingPhase 4Ages 30 Years - 75 YearsAllQilu Hospital of Shandong University
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In plain words

What the trial is, and whether it could suit you

Coronary microvascular disease (MVD) refers to exertional angina or myocardial ischemia caused by abnormal structure and/or function of precoronary arterioles and arterioles under the action of various pathogenic factors. The symptoms of patients with coronary microvascular disease are mainly exertion-related chest pain episodes. The basic and clinical researches of the traditional Chinese medicine compound Danshen dropping pills have found that it can improve vascular endothelial function and relieve angina pectoris, and it is widely used in clinical practice. This is a randomized, double-blind, placebo-controlled, multicenter clinical study of Compound Danshen Dropping Pills and blank control in patients with microvascular angina pectoris. The experimental drug and control drug of this clinical trial were selected according to the ratio of 1:1 patients were enrolled in the pre-exper

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion criteria: 1. with typical symptoms of exertional angina; 2. coronary CTA or angiography with normal coronary artery or \<50% stenosis, or \<50% residual coronary stenosis after revascularization; 3. resting electrocardiogram or During exercise stress, it was found that the ST segment had an ischemic downward shift (the horizontal or downward slope after the J-point shift \> 0.1 mv, lasting 0.08 s); 4. Transthoracic ultrasound examination of blood in the anterior descending coronary artery before and after intravenous injection of adenosine Flow reserve check CFR\<2.5; 5. The patient himself agrees to participate in this study. Exclusion criteria 1. Less than 30 years old or more than 75 years old; 2. Have a history of carotid endarterectomy or stent implantation, and have a history of stroke; 3. Myocarditis, pericardial disease, valvular disease, cardiomyopathy; 4. Difficult to control diabetes mellitus (fasting blood glucose\>7.0 mmol/L); 5. Uncontrolled hypertension (SBP\>150 mmHg and/or DBP\>90 mmHg); 6. Familial hypercholesterolemia; 7. Multiple Takayasu arteritis; 8. Those who are pregnant or lactating, or have fertility intention within one year, or have not taken effective contraceptive measures during the childbearing period; 9. Abnormal liver function (the level of serum GPT is 3.0 times higher than the upper limit of normal value) or abnormal renal function (the level of serum creatinine is more than 2 mg/dl); 10. Other respiratory, digestive, blood, infection, immunity, endocrine, neuropsychiatric, tumor diseases with clinical significance that may cause serious danger to patients; 11. Taking traditional Chinese medicine preparations of K channel opener, promoting blood circulation and removing blood stasis to improve microcirculation; 12. Allergies to intra arterial injection of contrast agents, blood and blood products; 13. Patients who are participating in other clinical studies.
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What it tests

  • Compound Danshen Dropping Pills
  • Placebo
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Where

1 site
Qilu Hospital of Shandong University
Jinan, China
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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