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The Potential Role of Compounds Derived From Ultra-processed Foods in Pathogenesis of Eosinophilic Esophagitis

Recruitingn/aAges 3 Years - 65 YearsAllFederico II University
NCT06093204 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Eosinophilic esophagitis (EoE) is a chronic antigen-mediated inflammatory disease of the esophagus that affects both children and adults. The incidence and prevalence of EoE is rapidly increasing in Western countries with an estimated incidence of 6.6 per 100,000 person-years (95% CI, 3-11.7) in children and 7.7 per 100,000 person-years (95% CI, 1.8-17.8) in adults. Clinically, it is characterized by various symptoms related to esophageal dysfunction, including vomiting, regurgitation, feeding difficulties, epigastric heartburn, dysphagia, or food bolus impaction, and may cause growth retardation. Diagnosis is made on the basis of clinical symptoms and histological evidence of eosinophilic infiltration of the esophagus (at least 15 eosinophils/high power microscope field (eos /hpf), excluding other etiologies of esophageal eosinophilia (gastroesophageal reflux disease, infectious esophag

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📋 Eligibility rules (as published)
Inclusion Criteria: * both sexes * age between 3-65 years * sure diagnosis of eosinophilic esophagitis * age- and sex-matched healthy controls * parents/tutor written informed consent. Exclusion Criteria: * lack of written informed consent; * non-Caucasian ethnicity * age at enrollment \< 3 or \>65 years * simultaneous presence of other chronic diseases: eosinophilic gastroenteritis, eosinophilic colitis, achalasia, GERD, hypereosinophilia syndrome, IBD, fungal or viral infections, connective tissue disorders, autoimmune diseases, vasculitis, bullous dermatosis with oesophageal involvement (pemphigus), drug hypersensitivity reactions, drug-induced oesophagitis, graft vs host disease, monogenic disorders (Marfan syndrome type 2, HIES, PTEN). * presence of tattoos, scars, moles or particular lesions on both forearms
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What it tests

  • Dietary evaluation
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Where

2 sites
Department of Traslational Medical Science - University of Naples Federico II
Naples, Italy
Department of Traslational Medical Science - University of Naples Federico II
Naples, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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