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Investigation of Cardioversion Versus Therapeutic Ablation for Persistent AF (ORBICA-AF)

RecruitingNAAges 18 Years - 85 YearsAllBarts & The London NHS Trust
NCT06096246 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The main aim of the research is to investigate whether patients undergoing pulmonary vein isolation with catheter ablation for persistent atrial fibrillation (AF) will have lower rates of AF recurrence than those treated by DC cardioversion without an ablation procedure.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Ability to give informed consent * Age 18-85 years * Persistent AF (atrial fibrillation lasting \> 7days) of total continuous duration \<2 years as documented in medical notes. * Patients being considered for cardioversion. Exclusion Criteria: * Creatinine clearance (eGFR) \< 30mls/min * Contraindication or unable to take anticoagulation * Uncontrolled hypertension * Contraindication for catheter ablation * BMI \> 40 * Patients in Persistent AF who have had more than one previous cardioversion. * Established diagnosis of Hypertrophic cardiomyopathy
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What it tests

  • Pulmonary vein isolation
  • DC Cardioversion
  • Implantable loop recorder
  • Femoral sheath insertion
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Where

1 site
Barts Heart Centre
London, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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