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Adipose Tissue Blood Flow in Aging Humans

RecruitingNAAges 18 Years - 80 YearsAllMayo Clinic
NCT06096532 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this basic science clinical trial is to understand whether adipose tissue blood flow changes between younger and older healthy adults. The main question\[s\] it aims to answer are: * Is basal and nutrient responsive adipose tissue blood flow (ATBF) different between younger and older adults * What molecular and systemic signatures related to adipose tissue blood flow are altered between these two groups. Participants will undergo measurements of adipose tissue blood flow using the xenon washout technique, undergo 2 abdominal subcutaneous adipose tissue biopsies, and drink a sugary drink.

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📋 Eligibility rules (as published)
Inclusion criteria * Within the ages of 18-35 years or 65-80 years at time of study visit * BMI between 20-25.0 kg/m2. Exclusion criteria: * Presence of diagnosed cardiometabolic diseases (e.g., Type 2 diabetes, hypertension, Heart Failure) * Taking prescription anticoagulants * Taking prescriptions or supplements that effect adipose tissue metabolism (i.e., statins, Thiazolidinediones, niacin, atypical antipsychotics, or fish oil) * Pregnant or nursing * Inability to provide written informed consent * Smokers
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What it tests

  • 75 gm oral glucose load
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Where

1 site
Mayo Clinic Minnesota
Rochester, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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