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โ† Trials
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Psychotherapy Effects on Reward Processing in PTSD

RecruitingNAAges 18 Years - 65 YearsAllUniversity of Texas at Austin
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to identify how trauma-focused psychotherapy changes the function of brain circuitry in posttraumatic stress disorder (PTSD) and how this mediates improvements in the diminished ability to experience positive emotions following a traumatic or extremely stressful life event. In this instance, the investigators will be using cognitive processing therapy (CPT), a widely-utilized and evidence-based treatment for PTSD.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * English as primary language, and comprehension suitable to understand experimenter instructions. * Current and chronic syndromic PTSD, defined as being exposed to a DSM-5 Criterion A traumatic event, with the presence DSM-5 qualifying PTSD symptoms for at least 3 months, as assessed by the Clinician-Administered PTSD Scale for DSM-5. * Able and willing to undergo functional magnetic resonance imaging (fMRI). * Willingness to participate in repeated assessments and as part of a delayed treatment group. Exclusion Criteria: * Evidence of current or prior history of psychosis or bipolar disorder as evidenced by self-report or clinical interview. * Active substance dependence within the past 6 months as evidenced by clinical interview. * Current regular psychiatric medication use (i.e. antidepressants), except for as-needed benzodiazepine or opiate medication no more than three times per week, on average, or for short-duration stimulant medication for attention deficit hyperactivity disorder that can be skipped within 24 hours of study visits. * A recent (\<6 months) suicide attempt or current active ideation with intent. * Unremovable ferrous metal in body. * History of neurological disorder, stroke, seizures/convulsions (except febrile seizures in childhood), epilepsy, brain surgery, electroconvulsive or radiation treatment, brain hemorrhage or tumor, or thyroid disorder. * Anyone who is pregnant or trying to become pregnant. * Current or past year (\> 3 sessions), psychotherapy with a prominent exposure or cognitive restructuring component. * Previous or current (es)ketamine treatment and/ or brain stimulation/neuromodulation treatment. * Other ongoing treatment that is likely to confound experimental effects. * Previous penetrating head injury/traumatic brain injury. Mild-to-moderate traumatic brain injury without penetrating injury is allowable.
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What it tests

  • Cognitive Processing Therapy
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Where

1 site
Health Discovery Building (HDB), 1601 Trinity St., Bldg B., Z0600
Austin, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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