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Erythrocyte Transport of Lactate During Exercise (TELE Project)

RecruitingNAAges 18 Years - 30 YearsAllTechnical University of Madrid
NCT06104150 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goals of this clinical trial are: 1. to study lactate kinetic between plasma and erythrocytes during an intervallic exercise and its subsequent recovery, considering the blood pH, the genotype for the T1470A polymorphism of the SLC16A1 gene (rs1049434), and the amount of MCT1 in erythrocytes membrane; 2. to analyze the levels of MCT1 in the erythrocytes membrane according to training status and genotype for the T1470A polymorphism of SLC16A1 (rs1049434). For this, the project will have two phases: * In phase I, trained participants will perform one maximal incremental test and one intervallic submaximal test with a final active recovery. * Phase II, levels of the MCT1 protein in the erythrocyte membrane will be quantified from trained and sedentary participants.

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📋 Eligibility rules (as published)
Inclusion Criteria: * BMI between 18 and 25 kg/m2 * Not smoker * In the case of trained participants: training at least 5 hours/week, of which at least 3 must be aerobic/anaerobic endurance training. Presentation of a medical certificate attesting to their medical fitness (capability) to perform intense physical exercise. * In the case of sedentary participants, less than 1 day of training per week or less than 2 hours of structured exercise per week. Exclusion Criteria: * Presenting any pathology that could impede the correct performance of the tests, or could influence the main study variables. * In the case of the female sample, having irregular menstrual cycles, oligomenorrhea or amenorrhea.
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What it tests

  • Intervallic submaximal exercise test
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Where

2 sites
Laboratorio de Pediatría. School of Medicine. Univesidad de Cantabria
Santander, Spain
Laboratorio de Fisiología del Esfuerzo. Facultad de Ciencias de la Actividad Física y del Deporte (INEF). Universidad Politécnica de Madrid
Madrid, Spain
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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