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Validation of a Novel Cerebellar-striatal Satiety Circuit in Humans

RecruitingNAAges 18 Years - 65 YearsAllBrigham and Women's Hospital
NCT06105164 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to study satiety in healthy individuals. TMS is a noninvasive way of stimulating the brain, using a magnetic field to change activity in the brain. The magnetic field is produced by a coil that is held next to the scalp. In this study, the investigators will be stimulating the brain to learn more about the role of the cerebellum in satiety.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Healthy individuals aged 18 to 65 * BMI of 20-35.0 kg/m2 * Normal or corrected-to-normal vision * Good general health * Ability to understand and willingness to sign written informed consent document Exclusion Criteria: * Current and/or past medical conditions * Current and/or past eating disorder * On a restricted diet and/or taking weight loss medication(s) * History of bariatric surgery * Weight fluctuation \>3% in past 3 months * Recent history of illicit recreational drug abuse * Current nicotine use * Intellectual disability * Conditions that might result in increased risks of side effects or complications from TMS or MRI
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What it tests

  • Repetitive Transcranial Magnetic Stimulation (rTMS)
  • Sham repetitive Transcranial Magnetic Stimulation (rTMS)
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Where

2 sites
McLean Hospital
Belmont, United States
Brigham and Women's Hospital
Boston, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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