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Neurobehavioral Profiles of Adaptive Stress Responses in Individuals With Alcohol Use Disorder

RecruitingNAAges 18 Years - 65 YearsAllCentral Institute of Mental Health, Mannheim
NCT06105853 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this observational study is to investigate longitudinal stress response profiles and adaptive versus non-adaptive stress responses in alcohol use disorder. The main questions the projects aims to answer are: What are the neurobehavioral underpinnings of adaptive stress responses and resilience to repeated stress exposure with regards to: * alcohol craving? * alcohol use? * their modulation by prior stress exposure, social interactions, coping strategies and individual health behavior? Participants will: * be exposed to an established experimental stress-induction protocol, the Trier Social Stress Test * be exposed to their favorite drink in a bar lab environment * be assessed using fMRI to determine their neural alcohol cue reactivity, response inhibition, and emotion processing * conduct an ambulatory phase to assess stressors, alcohol craving, substance use and details

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📋 Eligibility rules (as published)
Inclusion criteria are: * age between 16 and 65 years * meeting at least 2 criteria of an alcohol use disorder according to the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) (DSM-5), yet without the need for a therapeutic intervention * fluency in German * able to understand the study procedures and give informed consent * willingness to use a study smartphone Exclusion criteria are: * current use of drugs or medications that interact with the central nervous system or the glucocorticoid system * contraindications for magnetic resonance imaging * medical history of bipolar disorder, psychotic disorder, schizophrenia or schizophrenic spectrum disorder, or substance use disorder other than alcohol, nicotine, or cannabis * medical history of severe head injury or other severe central nervous system disorders or other severe somatic disorders (e.g. liver cirrhosis) * pregnancy
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What it tests

  • Trier Social Stress Test
  • Barlab Cue-Exposure
  • Functional magnetic resonance imaging
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Where

2 sites
Central Institute of Mental Health
Mannheim, Germany
Central Institute of Mental Health
Mannheim, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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