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Non-invasive Coronary Thrombus Imaging to Define These Cause of Acute Myocardial Infarction

Recruitingn/aAges 18 Years - anyAllUniversity of Edinburgh
NCT06113510 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

We now have very sensitive blood tests that can pick up damage to the heart and find patients who have had a heart attack. However, whilst this is welcome, it does not identify what causes the heart attack and can sometimes pick up other conditions that cause a strain on the heart. The classic cause of a heart attack is when a blood clot forms on fatty deposits within the heart arteries. This leads to treating patients with blood thinning medication, and this is very effective and saves lives. However, many apparent heart attacks are not caused by blood clots and some may be caused by blood clots but pass unrecognised. In this proposal, we will test an exciting new imaging test that can 'see' from outside the body whether there is a blood clot in the heart arteries. This could provide a major new way of assessing patients to ensure they get the right diagnosis and the right treatment.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Males and females ≥ 18 years of age * Clinical presentation of chest pain, ST-segment deviation within a coronary artery territory on the electrocardiogram, raised cardiac troponin and non-obstructive coronary arteries on invasive coronary angiography as per international societal diagnostic criteria Exclusion Criteria: * \<18 years of age * Takatsubo cardiomyopathy * Myocarditis * Renal failure (estimated glomerular filtration rate \<30 mL/min/1.73 m2) * Woman of child-bearing potential who are pregnant or breastfeeding * Known allergy or contraindication to iodinated contrast or radiotracer * Patients unable to tolerate the supine position * Patients unable to provide informed consent
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What it tests

  • Hybrid 18F-GP1 positron emission tomography and coronary computed tomography coronary angiography
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Where

1 site
Royal Infirmary of Edinburgh
Edinburgh, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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