🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Effect of a Probiotic on the Female Genital Tract Microbiota of Participants With Fertility Disorders.

RecruitingNAAges 18 Years - 45 YearsAllProbiSearch SL
NCT06122207 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

In the last decades, numerous publications have broken the old paradigm that considered the urogenital tracts as sterile, demonstrating that microorganisms present in the urogenital tract represent the 9% of the whole human microbiome. Healthy urogenital microbiome improves implantation rate and pregnancy outcomes, whereas 40% of dysbiosis prevalence is observed in women under assisted reproductive treatment (ART). Infertility causes are associated with male, female, or combined failure. It has been shown that oral probiotic treatment, mainly with Lactobacillus, recovers a healthy vaginal microbiota without safety concerns. An interventional, randomized, double-blind, placebo-controlled study will be conducted to confirm the positive effect of the commercial probiotic product Fertibiome® on the vaginal dysbiosis of couples or women with fertility disorders. The duration of the study w

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * Couples or women with ages between 18 and 45 for woman and between 18 and 55 for man (in case of couple participation). * Couples or women with fertility disorders. * Couples or women undergoing IVF treatment or willing to start it. * Signature of the Informed Consent. Exclusion Criteria: * Women, not participating in the study with a couple, who have not undergone at least 4 cycles of artificial insemination with donor's sperm (AID) or 1 cycle of IVF without achieving evolutionary pregnancy. * Women with Body Mass Index (BMI) ≥ 30. * Couples where the woman has not infertility diagnosis while the man has any of the following characteristics: * Azoospermia * Sperm motility (A + B) \< 25%. * Sperm morphology ≤ 2%. * Vas deferens obstruction. * Couples or women with any of the following characteristics: * Chronic diseases that cause intestinal malabsortion. * Congenital or acquired immunodeficiency. * Current history or diagnosis of alcohol, tobacco, or drug abuse. * Uncertainty about the willingness or ability of participants to comply with the requirements of the protocol. * Under treatment with probiotics during the last week.
💊

What it tests

  • Probiotic
  • Placebo
📍

Where

2 sites
Dr. Miguel Raimundo (Portugal)
Lisbon, Portugal
Hospital Universitario La Paz
Madrid, Spain
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy