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Testing the Interplay of Gambling, Emotion and Reward

Recruitingn/aAges 18 Years - 65 YearsAllHôpital le Vinatier
NCT06122298 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Background The nature and direction of dysfunctional reward processing in gambling disorder remains unclear. We aim to test a novel neurobiological model of gambling addiction, that takes into account inter-individual differences, as well as the multifactorial nature of gaming addiction. Objectives Primary objective: This project will test the hypothesis that there are two opposite brain phenotypes that characterize two distinct subpopulations of gamblers, so-called impulsive vs. emotional, respectively. Secondary objective: This project will also seek to determine whether the brain phenotypes proposed above are capable of predicting gambling behavior outside the laboratory. Study design The primary objective will be tested using a reward task and a facial emotion recognition task performed by participants in an fMRI scanner. The secondary objective will be tested by combining fMR

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📋 Eligibility rules (as published)
Inclusion Criteria: For all participants (gamblers and healthy subjects) * Aged between 18 and 65 * Fluent French, read and spoken * Male and Female * Informed consent to take part in the research For gamblers : * Number of DSM-5 critera for gambling disorder ≥3 * Score ≥ 5 on the Problem Gambling Severity Index questionnaire (PGSI) * Have a smartphone For healthy subjects : * no DSM-5 criteria for gambling addiction * Score ≤ 2 on the Problem Gambling Severity Index questionnaire (PGSI) Exclusion Criteria: For all participants (gamblers and healthy subjects): * Contra-indication to MRI * Protected Adults * Breast feeding or pregnant women * Neurological disorder or severe chronic illness (diabetes, heart disease, kidney disease, lung disease or liver disease, inflammatory disease….) * Pharmacological treatment with psychotropic action (\>1 time / week) * Regular drug use (\> 1 time/ week for at least 3 months in the last 6 months) * Positive urine drug test on the day of the MRI sessions For gamblers: * Psychiatric treatment \> 1 month (pharmacological or CBT) * Other DSM-5 diagnosis : schizophrenia, bipolar disorder, ADHD, autism, current PTSD, eating disorders, current major depressive episode, anxiety disorder, substance use disorder except nicotine, obsessive compulsive disorder. For healthy subjects : \- Any DSM-5 diagnosis except nicotine addiction
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What it tests

  • fMRI
  • Ecological Momentary Assessment
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Where

1 site
CH le Vinatier
Bron, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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