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← Trials
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Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty

RecruitingPhase 2Ages 18 Years - anyAllUniversity Health Network, Toronto
NCT06123715 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Phase II Multicentre, pilot, parallel-group, blinded, 1:1 randomized controlled trial to determine the feasibility of conducting a larger definitive trail of using vitamin C to reduce persistent pain in patients undergoing total knee arthroplasty surgery.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients \>18 years old * Undergoing a unilateral or bilateral primary total knee arthroplasty for advanced osteoarthritis of the knee Exclusion Criteria: * TKA for infection (septic joint), fracture, ankylosing spondylitis, lupus, or psoriatic arthritis * History of kidney stones, acute or chronic renal failure, hemochromatosis, or glucose-6-phosphate deficiency * Unlikely to comply with follow-up (e.g., no fixed address, plans to move out of town) * Language difficulties that would impede valid completion of questionnaires * Planned staged bilateral TKA * Treating surgeon deems patient inappropriate for inclusion in trial * Any allergy or sensitivity to milk * Pregnant or planning to become pregnant during the study
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What it tests

  • Vitamin C
  • Placebo
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Where

3 sites
Sunnybrook - Holland Centre
Toronto, Canada
Mount Sinai Hospital
Toronto, Canada
Toronto Western Hospital
Toronto, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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