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Exercise and Emotional Learning in Posttraumatic Stress Disorder

RecruitingNAAges 18 Years - 64 YearsAllChristal L Badour
NCT06127342 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to test how exercise affects learning and memory processes relevant to the treatment of PTSD. Participants will complete a baseline intake followed by two experimental sessions. During the first experimental session, participants will undergo an MRI session of imaginal exposure to traumatic memory cues followed by 30-minutes of moderate intensity exercise or low intensity exercise. Participants will complete a second session of imaginal exposure with MRI 24 hours later.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults with PTSD related to interpersonal violence Exclusion Criteria: * Active or recent (within the last 3 months) severe substance use disorder(s) * Active or recent (within the last 3 months) suicidal, psychotic, or manic symptoms/ episodes * Significant developmental disabilities * Current daily benzodiazepine or stimulant use with inability to abstain for study sessions * Recent changes in psychiatric medication or trauma focused cognitive-behavioral therapy (CBT) (past 4-weeks) * Medical condition(s) that prohibit exercise * History of traumatic brain injury (TBI) with loss of consciousness \> 30 mins * Magnetic resonance imaging (MRI) contraindication(s) * Positive pregnancy test * History of seizure disorder * Spontaneous seizure(s) within the last 3 months
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What it tests

  • Moderate Intensity Exercise
  • Low Intensity Exercise
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Where

2 sites
University of Kentucky
Lexington, United States
University of Texas
Austin, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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