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Brain Vascular and Neural Function Linked to Balance Across the Adult Lifespan

RecruitingNAAges 21 Years - 95 YearsAllUniversity of Minnesota
NCT06127667 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a single-arm, two-visit, non-randomized, cross sectional study identified as an intervention due to the use of a single bout of aerobic exercise to assess cerebrovascular function under the NIH rules. This study is not masked and its primary purpose is to develop a basic science understanding of the relationship between cerebrovascular health and balance control with aging. This study will involve 102 individuals classified as younger adults, middle-aged adults, and older adults who are neurotypical and cognitively normal. The primary outcome from a clinical trials perspective will be cerebrovascular response to a bout of aerobic exercise (i.e. change in cerebral blood flow with the performance of aerobic exercise on a recumbent stepper exercise machine). Non-interventional outcomes will be EEG measures of cortical activity and biomechanical kinetic and kinematic data recorded du

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age within the following 3 group age ranges, 21-30yo; middle-aged: 40-55yo; older: 65-95yo adults * the absence of major orthopedic disability * cognitively normal (MoCA score ≥ 26/30 in older adult group) * vision that is 20/40 or better with or without corrective lenses, (5) the ability to consent and communicate with researchers * English speaking * ability to stand for 3 minutes and walk 10 meters with or without an assistive device and without the assistance of another person. Exclusion Criteria: * insulin-dependent diabetes * peripheral neuropathy * myocardial infarction or symptoms of coronary artery disease within 2 years * congestive heart failure or class IV heart failure * any significant sensory impairment affecting balance or cognition; visual, vestibular, or auditory impairments.
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What it tests

  • aerobic exercise
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Where

1 site
University of Minnesota
Minneapolis, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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