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Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

RecruitingPhase 1, Phase 2Ages 18 Years - anyAllRevolution Medicines, Inc.
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In plain words

What the trial is, and whether it could suit you

This study is to evaluate the safety, tolerability, and PK profiles of Elironrasib and Daraxonrasib as monotherapies and combination therapy in patients with KRAS G12C-mutated solid tumors.

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📋 Eligibility rules (as published)
Inclusion Criteria: * 18 years of age * Histology: pathologically documented, KRAS G12C-mutated, advanced or metastatic solid tumors not amendable to curative therapy 1. Phase 1b Dose Escalation: solid tumors, previously treated 2. Phase 1b Dose Expansion and Phase 2: i. NSCLC, previously treated with immunotherapy, chemotherapy, and KRAS G12C (OFF) inhibitors ii. Solid tumors, previously treated, naïve to KRAS G12C (OFF) inhibitors. * ECOG performance status 0 or 1 * Adequate organ function Exclusion Criteria: * Primary central nervous system (CNS) tumors * Active brain metastases * Known impairment of GI function that would alter the absorption * Major surgical procedures within 28 days or non-study related minor procedures within 7 days of treatment
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What it tests

  • Elironrasib
  • Daraxonrasib
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Where

56 sites
City of Hope
Duarte, United States
UC IRVINE Health
Orange, United States
UC Davis Comprehensive Cancer Center
Sacramento, United States
Stanford Cancer Institute
Stanford, United States
University of Colorado Cancer Center
Aurora, United States
Florida Cancer Specialists
Sarasota, United States
Moffitt Cancer Center and Research Institute
Tampa, United States
Community Health Network
Indianapolis, United States

…and 48 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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