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Trans-coronary Cooling and Dilution for Cardioprotection During Revascularisation for ST-elevation Myocardial Infarction

RecruitingNAAges 18 Years - anyAllRoyal Brompton & Harefield NHS Foundation Trust
NCT06128993 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

A heart attack (myocardial infarction) occurs when an artery supplying blood to the heart is suddenly blocked resulting in damage to the heart muscle. Patients presenting to hospital with a heart attack undergo an immediate angiogram (x-ray of the arteries in the heart) and are usually treated immediately with a balloon and stent to open their blocked artery. This procedure is called "primary percutaneous coronary intervention" (or primary PCI for short). An angiogram is a routine procedure that involves insertion of fine plastic tube (catheter) into either the groin or wrist under local anaesthetic. The tube is passed into the artery in the heart and X-ray pictures are taken to find out if the arteries are blocked. Blocked arteries can usually be opened by passing a small balloon into the artery, via the fine plastic tube followed by placement of a stent (a fine metal coil) into the a

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📋 Eligibility rules (as published)
Inclusion Criteria: * Clinical ST-elevation myocardial infarction or equivalent (e.g. new onset LBBB) * \<12 Hrs after symptom onset * Thrombolysis in myocardial infarction (TIMI) 0-1 coronary flow in a target vessel Exclusion Criteria: * History of severe asthma * Pregnancy * Severe concomitant disease or conditions with a life expectancy of less than one year.
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What it tests

  • Transcoronary cooling and dilution
  • Standard of care
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Where

1 site
Harefield Hospital
Uxbridge, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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