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Stress, Inflammation and Neuroimaging in Major Depressive Disorder as Compared to Premenstrual Dysphoric Disorder

Recruitingn/aAges 18 Years - 40 YearsFemaleUniversity Hospital Tuebingen
NCT06130371 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Premenstrual dysphoric disorder (PMDD) is a sex-specific depressive disorder where depressive symptom severity drastically changes in relation to menstrual cycle phase. It is characterized by late luteal phase symptoms of affective lability, irritability, depressed mood, and anxiety. A lot remains unclear and further studies are needed in order to improve the understanding of PMDD and to differentiate it from major depressive disorder (MDD). To date, and in contrast to MDD, the neural correlates of PMDD have been sparsely and poorly investigated. The aim of this study is therefore to investigate the neural correlates of PMDD as compared to MDD and to relate them to stress reactivity. Therefore, three groups of naturally cycling women will be investigated and compared, namely (1) women with MDD, (2) women with PMDD, and (3) healthy control women. Stress and HPA axis activity are assumed

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📋 Eligibility rules (as published)
Inclusion Criteria: * Women, * age between 18 and 40 years (no menopausal women), * regular menstrual cycles (25-31 days), * normal body mass index (18-35 kg/m2), * German language fluency Exclusion Criteria: * any neurological or mental disease (only for healthy participants) * hormonal, metabolic or chronical diseases * pregnancy * women who gave birth or were breastfeeding within the last year * women with any kind of steroid hormonal treatment * oral contraceptive treatment in the last three months * psychotropic treatment, only if regular * engagement in competitive sports * shift work
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What it tests

  • Not listed
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Where

1 site
University Hospital Tübingen, Klinik für Psychiatrie und Psychotherapie
Tübingen, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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