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Study to Investigate an Association Between Brain Activity and Tidal Volume in Humans (BATMAN)

RecruitingNAAges 18 Years - anyAllUniversity Health Network, Toronto
NCT06142773 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The communication between the lungs and the brain has drawn a lot of attention recently. Animal studies have shown that the breathing cycle is coupled with brain activity, showing that the greater the volume of air delivered to the lungs via a breathing machine greater the brain activity and also the greater the injury to the brain cells. There is no study in humans that investigates the physiological communication between the volume of air delivered to the lungs and brain activity. This is important because really sick patients receive breathing assistance using breathing machines to keep their oxygen levels within a normal range. Although these machines are life-saving tools, they might result in brain cell injury, leading to cognitive impairment. So, establishing the existence of a physiological communication between the volume of air delivered using these breathing machines and brai

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Patients scheduled to undergo an MRI scan of their head under general anesthesia 2. Age \> 18 years Exclusion Criteria: 1. Stroke, and/or brain tumor in the regions of interest that has not been diagnosed before the MRI scan 2. Previous medical history of dementia 3. Previous medical history of brain surgery 4. Acute or chronic spinal cord Injury 5. Previous Vagotomy 6. Phrenic nerve injury
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What it tests

  • Tidal Volume set on ventilator
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Where

1 site
Toronto General Hospital
Toronto, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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