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Regression of Cervical Precancerous Lesions and Associated Risk Factors

Recruitingn/aAges 18 Years - 40 YearsFemaleGeneral University Hospital, Prague
NCT06147388 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aim of this study is to assess the extent of histopathological regression of severe cervical precancerous lesions (CIN 2 and CIN 3); evaluate the proportion of patients who experience the normalization of HPV test and cytology finding among those who were treated conservatively and those who underwent conization; and identify predictive parameters associated with regression. Based on this analysis, a model will be proposed to predict the likelihood of lesion regression.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. squamocolumnar junction fully visualized 2. bioptically verified CIN 2 or CIN 3 3. age ≥ 18 years 4. age ≤ 40 years 5. informed consent Exclusion Criteria: 1. squamocolumnar junction not fully visualized 2. suspicion on glandular lesion 3. suspicion on invasive cancer 4. personal history of CIN 2, 3 or cerv. cancer 5. gravidity 6. HIV positivity 7. immunosuppression 8. impossible photographic documentation
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What it tests

  • Colposcopy
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Where

1 site
General University Hospital
Prague, Czechia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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