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Ablate and Pace HIS Study

RecruitingNAAges 18 Years - 100 YearsAllUniversity Hospitals, Leicester
NCT06152406 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, and estimates suggest its prevalence is increasing. Despite the advances in AF ablation strategies, the outcome of ablation procedures in persistent AF is still unsatisfactory. In addition, many patients are not candidates for ablation due to advanced age, comorbidities and previous failed ablation procedures. It is well known that there is no mortality benefit from rhythm versus rate control strategy in AF, therefore the increased number of AV node ablation and pacemaker insertion for patients with symptomatic AF with uncontrolled heart rate. Following AV node ablation, it is understandable that these patients will be paced 100% of the time where the value of physiological pacing will be at its most. The current standard practice is to pace the right ventricle for this cohort of patients unless they have severe

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📋 Eligibility rules (as published)
Inclusion Criteria: * Aged 18 or above * Symptomatic AF, New York Heart Association (NYHA) class II-IV * Willing to consent for the study * AF regardless type, deemed not suitable for rhythm control strategy that has been referred for AVN ablation with one of the following: 1. Impaired LV function, EF \<50 %. And or 2. Raised N-Terminal Pro B-type Natriuretic Peptide ( NT-ProBNP) \>365 ng/L Exclusion Criteria: * Patient who has already got a pacemaker in situ * Known severe LVSD when biventricular device is the thought to be the preferred pacing modality * Females in child bearing period * Lack of capacity to consent * Other serious medical condition with life expectancy of less than 1 year * Less than 18 years * Unwilling to consent for the study
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What it tests

  • Ablation and Pacemaker Implantation
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Where

1 site
University Hospitals of Leicester NHS Trust
Leicester, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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