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Exogenous Ketone Supplementation in Females with Polycystic Ovary Syndrome

RecruitingNAAges 18 Years - 40 YearsAllMcGill University
NCT06155708 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Polycystic ovary syndrome (PCOS) affects 1 in 5 females of reproductive age. Commonly characterized as a disorder of infertility, PCOS is often accompanied by 3 potent cardiovascular disease (CVD) risk factors: insulin resistance, endothelial dysfunction, and elevated blood pressure. Accordingly, PCOS is associated with the development of CVD, the second leading cause of death in females in Canada. However, effective treatments to improve cardiovascular health in PCOS are lacking. Exogenous ketone monoester (KME) ingestion has been shown to improves outcomes associated with insulin resistance, endothelial function, and blood pressure regulation in healthy individuals and individuals predisposed to CVD. Therefore, oral ketone supplements offer a practical and effective strategy for improving cardiovascular health; however, this treatment has yet to be evaluated in PCOS. Therefore, the o

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📋 Eligibility rules (as published)
Inclusion Criteria: * All female participants will report female sex assigned at birth * All participants will be aged 18 to 40 * PCOS diagnosis Exclusion Criteria: * Current smokers or a prolonged history of smoking * Presence or history of overt cardiometabolic disease (e.g., stage 2 hypertension, diabetes, heart disease), neurologic disease, or endocrinopathy (with the exception of PCOS) * Current pregnancy or currently breastfeeding * Current use of medications which may affect our outcomes of interest (e.g., anti-hypertensives, anti-androgens, metformin)
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What it tests

  • Ketone
  • Water
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Where

1 site
Cardiovascular Health and Autonomic Research Laboratory
Montreal, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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