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Sleep and Neuropathic Pain - Intervention Study on Pregabalin

RecruitingNAAges 18 Years - 75 YearsAllHelsinki University Central Hospital
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical study is to study sleep and its microstructure in neuropathic pain patients who have or who do not have a clinically significant sleep disturbance, before and during (after 1-month stabile dosage) pregabalin treatment. To find out whether reduced pain by pregabalin associates with improved sleep quality; to study, using resting state fMRI, brain network connectivity and the volume of the choroid plexus before and during pregabalin treatment (after dosage stable for one month) at baseline and during stabile treatment with pregabalin, and to compare the usability and reliability of sleep-related information collected with sleep diaries, actigraphy, iButtons, and ambulatory polysomnography in peripheral painful neuropathy patients. The main questions it aims to answer are: * Is pregabalin more efficacious in neuropathic pain patients who suffer from insomnia compa

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Chronic (duration \> 3 months) painful peripheral neuropathy * Pain moderate to severe (NRS โ‰ฅ 4/10) during the past week Exclusion Criteria: * psychotic depression, clinically significant bipolar disorder * contraindication for performing brain fMRI (metal in the body etc)
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What it tests

  • Pregabalin
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Where

2 sites
Helsinki University Central Hospital
Helsinki, Finland
Helsinki University Hospital, Department of Neurology
Helsinki, Finland
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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