Pursuing Reduction in Fatigue After COVID-19 Via Exercise and Rehabilitation (PREFACER): A Randomized Feasibility Trial

Inclusion Criteria: * Adults of at least 18 years of age * Able to provide informed consent * Can speak and understand English * Documented history of SARS-CoV-2 infection (positive PCR/antigen test during acute illness or clinical diagnosis by physician during or after the acute illness) * Fatigue symptoms within 3 months of COVID-19 infection, lasting at least 2 months * Fatigue symptoms cannot be explained by an alternative diagnosis * Fatigue symptoms may be new onset following initial recovery from an acute COVID-19 infection or persist from the initial illness * Fatigue symptoms may have an episodic nature, fluctuate or relapse over time * Minimal functional capability: able to walk 10-15 minutes and be recovered within 30-60 minutes or without significant post-exertional malaise (PEM) * Has applicable technology to access Microsoft Teams and Webex (i.e., computer, laptop, tablet) Exclusion Criteria: * Active SARS-CoV-2 infection * Pre-existing physical, cognitive, and/or mental health conditions that make exercise contraindicated, consent unattainable, or that cause symptoms similar to those seen in post COVID-19 (e.g., major neurocognitive disorder, schizophrenia, chronic fatigue syndrome) that could affect data * Inability to follow study procedures * Pregnant and/or breastfeeding * Received investigational agents as part of a separate study within 30 days of the screening visit * Has any type of metal bodily implant in head or heart (i.e., pins, plates, pacemakers) * Current participation in other studies related to COVID-19, exercise, and/or fatigue interventions OR participation within 30 days of the screening visit