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A Clinical Trial of LBL-024 Combined With Etoposide and Platinum in Patients With Advanced Neuroendocrine Carcinoma

RecruitingPhase 1, Phase 2Ages 18 Years - 75 YearsAllNanjing Leads Biolabs Co.,Ltd
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In plain words

What the trial is, and whether it could suit you

An open-label, multicenter phase Ib/II clinical study to evaluate the safety and efficacy of LBL-024 combined with etoposide and platinum in the first-line treatment of patients with advanced neuroendocrine carcinoma (NEC)

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: 1. Agree to follow the trial treatment regimen and visit schedule, voluntarily enroll, and sign the written informed consent. 2. aged 18-75 years (including borderline values) at the time of signing the informed consent form 3. The Eastern Cooperative Oncology Group's physical status scoring standard (ECOG) is 0\~1. 4. The expected survival time is at least 12 weeks. 5. According to the evaluation of RECIST 1.1 (Response Evaluation Criteria in Solid Tumours),the subjects enrolled have at least one measurable target lesion. 6. Fertile men and women of childbearing age are willing to take effective contraceptive measures from the signing of the informed consent form to 6 months after the last dose of the investigational drug; women of childbearing age include premenopausal women and women who had menopause less than two years ago. Blood pregnancy test results must be negative for women of childbearing age within 7 days prior to the initial dose of the investigational drug. Exclusion Criteria: 1. Subjects who underwent major organ surgery (excluding needle biopsy) or significant trauma within 4 weeks prior to the initial use of the investigational drug, or require elective surgery during the trial period 2. Use of immunomodulatory drugs within 14 days prior to the initial use of the investigational drug, including but not limited to thymosin, interleukin, and interferon 3. Subjects with an active infection that currently requires intravenous anti-infective therapy. 4. Clinically uncontrollable pleural effusion, pericardial effusion, and requiring repeated drainage or medical intervention. 5. medical history of immunodeficiency including HIV antibody positive. 6. Pregnant or lactating women. 7. The investigator believes that the subject has other conditions that may affect compliance or that are not suitable for participating in this study.
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What it tests

  • LBL-024 for Injection
  • Etoposide Injection
  • Carboplatin Injection
  • Atezolizumab injection
  • Cisplatin injection
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Where

25 sites
Anhui Provincial Hospital
Hefei, China
Anhui Cancer Hospital
Hefei, China
Beijing GoBroad Hospital
Beijing, China
Beijing Cancer Hospital
Beijing, China
Chongqing University Cancer Hospital
Chongqing, China
Fujian Cancer Hospital
Fuzhou, China
Sun Yat-sen University Cancer Center (SYSUCC)
Guangzhou, China
The First Affiliated Hospital of Guangdong Pharmaceutical University
Guangzhou, China

…and 17 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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