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Ventilation Using Radiographic Examination: Functional Lung Imaging Techniques for the Reduction of Toxicity in Functional Avoidance Radiation Therapy

Recruitingn/aAges 18 Years - anyAllUniversity of Sydney
NCT06159660 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this observational validation study is to determine the best implementation of fluoroscopic and CT ventilation imaging in patients having non-stereotactic ablative body radiotherapy (non-SABR) radiotherapy for stages II-IV lung cancer. The main questions it aims to answer are: * Assess the dosimetric variation in functional avoidance radiation therapy (RT) plans produced using these ventilation imaging techniques, * Establish a quality assurance procedure for functional lung avoidance radiation therapy, and * Evaluate the clinical acceptable thresholds for accuracy of the method. Participants will: Prior to radiation therapy treatment, patients will undergo: 1. A standard of care 4DCT scan for radiation therapy simulation, 2. Pulmonary Function Tests (PFT) 3. A 4D attenuation correction CT 4. Breath Hold Computed Tomography (BHCT) imaging where static end-inspiration and

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📋 Eligibility rules (as published)
Inclusion Criteria: * Aged 18 years or older. * Eastern Cooperative Oncology Group (ECOG) performance status 0-2. * Histologically proven Stage II-IV non-small cell lung cancer as determined using the IASLC International Association for the Study of Lung Cancer (IASLC) 8th edition lung cancer staging guidelines. * To be treated with curative intent (stage II-III) or palliative intent (stage IV) with non-SABR external beam radiotherapy (e.g. 60 Gy in 30 treatments for curative intent or 30 Gy in 5 treatments for palliative intent). * Pulmonary function tests within 8 weeks of registration. * 4DCT simulation for radiation therapy. * Willingness to give written informed consent. * Willingness and ability to comply with the study procedures and visit requirements. * Available for follow up for 1 year or until death, whichever occurs first. Exclusion Criteria: * Prior radiation therapy to the thorax. * Prior surgery for this cancer. * Prior chemotherapy for this cancer. * Interstitial lung disease. * Pregnant women.
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What it tests

  • Not listed
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Where

1 site
Royal North Shore Hospital
St Leonards, Australia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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