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Association of Dysbiosis and Immune Response in Bronchiolitis in Under 12 Months -Old Infants

Recruitingn/aAges 1 Day - 12 MonthsAllAssistance Publique - Hôpitaux de Paris
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In plain words

What the trial is, and whether it could suit you

Acute bronchiolitis is a common disease in children under the age of two, caused mainly by the respiratory syncytial virus (RSV). Furthermore, given the same medical history, it is still very difficult to predict the course and severity of the infection at the onset of symptoms, Some studies have highlighted the importance of the microbiota (intestinal, oral or nasopharyngeal) and of the immune response to RSV in children, We will include 80 children under 2 years old with hospitalized bronchiolitis and non-hospitalized bronchiolitis. Oral, nasal and stool samples will be taken to study the various microbiota in search of dysbiosis. A capillary blood sample will be taken for immune studies.

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: * Infants \<12 months * With bronchiolitis during RSV epidemic season * No chronic illness * No bronchiolitis medical history * Signed consent from parents or legal guardians Exclusion Criteria: * Chronic respiratory illness * Medical history of bronchiolitis or newborn asthma * Treatment with immunosuppressants * Patient with no social security affiliation
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What it tests

  • Sampling
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Where

3 sites
APHP, Antoine Béclère Hospital
Clamart, France
AP-HP,Raymond Poincaré Hospital
Garches, France
Réanimation médico-chirurgicale Necker
Paris, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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