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EACH-ADHF: Early Comprehensive Rehabilitation in Patients With ADHF

RecruitingNAAges 18 Years - 80 YearsAllGuangdong Provincial People's Hospital
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In plain words

What the trial is, and whether it could suit you

EACH-ADHF: Early Comprehensive Rehabilitation in patients with ADHF study is a multi-center, parallel-group, randomized controlled trial designed to evaluate the effects of the early comprehensive rehabilitation including exercise and inspiratory muscle training, over a period of 6 weeks, on the quality of life of patients with ADHF.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. Age between 18-80 2. At least one symptom of heart failure upon admission: Dyspnea at rest or with exertion, orthopnea, paroxysmal nocturnal dyspnea or exertional fatigue. 3. At least two of the signs of heart failure (HF): Distended jugular veins, enlarged cardiac silhouette, apex beat displacement, third heart sound, or increased jugular venous pressure/central venous pressure/pulmonary capillary wedge pressure. Pulmonary edema or pulmonary congestion (rales or chest X-ray/CT evidence of pulmonary congestion). Peripheral edema. Elevated B-type natriuretic peptide (\>100 pg/ml) or elevated NT-proBNP (\>300 pg/ml). 4. Able to independently perform basic activities of daily living before admission. 5. Able to complete the baseline assessment and initiate the specified treatment. 6. Able to walk 4 meters at the time of enrollment (assistive devices may be used). 7. Agree to participate in this study, sign a written informed consent form, and is willing to cooperate with follow-up. Exclusion Criteria: 1. Acute heart failure caused by acute myocardial infarction. 2. Severe aortic valve stenosis. 3. Hemodynamic instability caused by poorly controlled arrhythmias. 4. Severe heart failure and high-degree atrioventricular block, and inadequate heart rate response to pacing during exercise. 5. Isolated pulmonary hypertension. 6. Poorly controlled symptomatic orthostatic hypotension. 7. Hypertrophic obstructive cardiomyopathy. 8. Stage 5 chronic kidney failure, defined as glomerular filtration rate \<15 ml/(minยท1.73mยฒ) or requiring dialysis. 9. Undergoing screening tests with alanine aminotransferase (ALT) or aspartate aminotransferase (AST) levels greater than or equal to 5 times the upper limit of the normal range defined by the center. 10. Awaiting a heart transplant or ventricular assist device implantation within six months, or having received a heart transplant. 11. A history of chronic lung disease except for COPD, previous lung surgery, or diseases affecting lung function, such as scoliosis. 12. Late-stage diseases other than heart failure. 13. Any medical history that could potentially affect protocol compliance, such as severe mental disorders, severe cognitive impairment, substance abuse, or addiction. 14. Severe language, psychological, or physical disabilities that prevent their participation in the program. 15. Pregnant or lactating women, or those of childbearing potential who are unwilling or unable to use effective contraceptive measures. 16. Involved in other interventional clinical trials. 17. Patients deemed unfit for participation in this study by the researchers.
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What it tests

  • Early comprehensive rehabilitation
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Where

1 site
Guangdong Provincial People's Hospital
Guangzhou, China
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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