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Study of RAS(ON) Inhibitors in Patients With Advanced RAS-mutated NSCLC

RecruitingPhase 1, Phase 2Ages 18 Years - anyAllRevolution Medicines, Inc.
NCT06162221 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this platform study is to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary antitumor activity of novel RAS(ON) inhibitors as a monotherapy or combined with Standard(s) of Care (SOC) or with each other. The first four subprotocols include the following: Subprotocol A: RMC-6291 +/- RMC-6236 + SOC Subprotocol B: RMC-6236 + SOC Subprotocol C: RMC-9805 +/- RMC-6236 + SOC Subprotocol D: RMC-9805

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📋 Eligibility rules (as published)
Inclusion criteria: All Patients (unless otherwise noted): * ≥ 18 years of age * ECOG PS is 0 to 1 * Adequate organ function as outlined by the study * Received prior standard therapy appropriate for tumor type and stage * Must have pathologically documented, locally advanced or metastatic KRAS G12C-mutated solid tumor malignancy (not amenable to curative surgery) (Subprotocol A) * Must have pathologically documented, locally advanced or metastatic RAS-mutated NSCLC (Subprotocol B) * Must have pathologically documented, locally advanced or metastatic RAS G12D-mutated NSCLC (Subprotocol C and Subprotocol D) Exclusion criteria: All Patients: * Primary central nervous system (CNS) tumors * Impaired gastrointestinal (GI) function that may significantly alter the absorption of RMC drugs * Major surgery \< 28 days of first dose * Active or history of interstitial lung disease (ILD) or pneumonitis requiring steroids Other inclusion/exclusion criteria may apply.
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What it tests

  • RMC-6291
  • RMC-6236
  • Pembrolizumab
  • Cisplatin
  • Carboplatin
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Where

98 sites
Banner MD Anderson Cancer Center
Gilbert, United States
City of Hope - Duarte
Duarte, United States
City of Hope - Lennar
Irvine, United States
University of California Los Angeles
Los Angeles, United States
UC Davis, Davis Comprehensive Cancer Center
Sacramento, United States
University of California, San Diego Moores Cancer Center
San Diego, United States
UCSF Medical Center - Mission Bay
San Francisco, United States
Stanford University - Stanford Cancer Institute
Stanford, United States

…and 90 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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