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A Clinical Study of MK-4208/TERN-701 in Participants With Chronic Myeloid Leukemia (CML) (MK-4208-003/Tern701-1012/CARDINAL)

RecruitingPhase 1, Phase 2Ages 18 Years - anyAllTerns, Inc., a subsidiary of Merck & Co., Inc. (R…
NCT06163430 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Researchers are looking for a new way to treat a blood cancer called chronic myeloid leukemia (CML). Researchers want to learn if MK-4208 (Tern-701) can treat this type of blood cancer. The goal of this study is to learn about the safety of different doses (amounts) of MK-4208 (Tern-701) and if people tolerate them. Researchers also want to find the highest dose of MK-4208 (Tern-701) that people can tolerate and may work to treat blood cancer.

Sign in to get the eligibility rules as simple questions to take to your doctor.

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📋 Eligibility rules (as published)
Key Inclusion Criteria: Inclusion Criteria include but are not limited to: * Have an Eastern Cooperative Oncology Group (ECOG) performance status score of 0 to 2 * Have an established cytopathologically confirmed diagnosis of breakpoint cluster region::Abelson (BCR-ABL1) positive Chronic Myeloid Leukemia (CML) in Chronic Phase * Have received treatment with at least one prior tyrosine kinase inhibitor (TKI) and have treatment failure, suboptimal response, or treatment intolerance * Prior treatment with asciminib is allowed * Adequate organ function, as assessed by local laboratory Key Exclusion Criteria: Exclusion criteria include but are not limited to: * Systemic antineoplastic therapy (including prior TKIs, interferon-alfa, therapeutic antibodies, chemotherapy) or other experimental therapy 7 days before the first dose of MK-4208/TERN-701 * Have completed previous anticancer therapy without resolution of all associated clinically significant toxicity (to ≤ Grade 2 or baseline)
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What it tests

  • MK-4208
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Where

54 sites
University of Alabama Medicine (UAB Medicine)
Birmingham, United States
Banner MD Anderson Cancer Center
Gilbert, United States
UC Irvine Health
Orange, United States
Rocky Mountain Cancer Centers, LLP
Lone Tree, United States
Florida Cancer Specialists - South Region Research Office
Fort Myers, United States
Florida Cancer Affiliates - Ocala
Ocala, United States
Florida Cancer Specialists - North Region Research Office
St. Petersburg, United States
Florida Cancer Specialists - East Region Research Office
West Palm Beach, United States

…and 46 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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