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Appropriate Use of Blood Cultures in the Emergency Department Through Machine Learning

RecruitingNAAges 18 Years - anyAllAmsterdam UMC, location VUmc
NCT06163781 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to study whether the use of our blood culture prediction tool is non-inferior to current practice and if it can improve certain outcomes in all adult patients presenting to the emergency department with a clinical indication for a blood culture analysis (according to the treating physician). The primary endpoint is 30-day mortality. Key secondary outcomes are: * hospital admission rates * in-hospital mortality * hospital length-of-stay. In the intervention group, the physician will follow the advice of our blood culture prediction tool. In the comparison group all patients will undergo a blood culture analysis.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age \>= 18 years * Have a clinical indication for a blood culture analysis (according to the treating physician) * Have sufficient data recorded (laboratory results and vital sign measurements) for a prediction to be made (at least 20% of the needed parameters) Exclusion Criteria: * Central Venous Line (CVL) or Peripherally Inserted Central Catheter (PICC) in situ * Neutrophil count \< 0.5 \* 109/L * Candidemia or S. aureus bacteraemia in the past 3 months. * Most likely diagnosis of endocarditis/spondylodiscitis/infected prosthetic material * Pregnant or breastfeeding patients * Not capable of giving informed consent
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What it tests

  • Blood culture prediction tool
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Where

1 site
Amsterdam UMC - location AMC
Amsterdam, Netherlands
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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