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18F-FAPI PET/MRI Imaging in Myelofibrosis: a Prospective Observational Study.

Recruitingn/aAges 18 Years - 80 YearsAllFirst Affiliated Hospital of Zhejiang University
NCT06164561 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study intends to use a prospective, observational, self-controlled, multi-center study design to evaluate the feasibility and diagnostic efficacy of 18F-FDG PET/CT and 18F-FAPI PET/MRI imaging for the evaluation of systemic fibrosis in MF patients based on the results of bone marrow pathological biopsy, and to analyze the relationship between imaging results and clinical prognosis.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients with primary myelofibrosis or myelofibrosis secondary to myeloid tumors were diagnosed according to the diagnostic criteria of who 2022. * Stable vital signs, ECOG score ≥ 2 points, tolerate and cooperate to complete 18F-FDG PET/CT and 18F-FAPI PET/MRI examination. * The interval between imaging ,hematologic, cytogenetic and pathology was \< 2 weeks. * Willing to accept 18F-FDG PET/CT and 18F-FAPI PET/MRI , sign the informed consent. Exclusion Criteria: * Inability or unwillingness to provide informed consent. * Other malignancies, autoimmune diseases, or chronic active infections were diagnosed within 1 year before the diagnosis of myelofibrosis. * Current infection was present within 1 week before PET examination. * Pregnant or lactation. * Unable to follow protocol to complete follow-up. * Have received glucocorticoid therapy within 2 weeks before PET imaging examination. * Using granulocyte colony-stimulating factor (G-CSF) within 4 weeks prior to PET imaging.
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What it tests

  • Not listed
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Where

1 site
The First Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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