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Sequential Therapies After Osteoanabolic Treatment

Recruitingn/aAges 50 Years - 85 YearsFemale424 General Military Hospital
NCT06164795 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

12-month prospective, open-label, multicenter, international, observational study evaluating sequential treatments after osteoanabolics

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📋 Eligibility rules (as published)
Inclusion Criteria: • Postmenopausal women treated with severe osteoporosis completing their course with romosozumab or teriparatide Exclusion Criteria: * a bone disease other than postmenopausal osteoporosis * use of medications other than romosozumab or teriparatide affecting bone metabolism during the last 12 months before entering the study * creatinine clearance \<60 mL/min/1.73 m2 * liver failure * any type of cancer * uncontrolled endocrine diseases * serum 25-hydroxy vitamin D (25-OHD) concentrations lower than 20 ng/mL (50 nmol/L) * hypersensitivity to denosumab or zoledronate or teriparatide or romosozumab or any of the excipients
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What it tests

  • Zoledronate
  • Denosumab
  • Teriparatide
  • Romosozumab
  • Abaloparatide Injection (80 mcg)
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Where

8 sites
251 Airforce & VA General Hospital
Athens, Greece
First Department of Propaedeutic and Internal Medicine, Medical School, National and Kapodistrian University of Athens
Athens, Greece
, KAT General Hospital
Athens, Greece
424 General Military Hospital
Thessaloniki, Greece
Fondazione IRCCS Cà Granda-Ospedale Maggiore Policlinico
Milan, Italy
Campus Bio-Medico University
Roma, Italy
Department of Medicine, Surgery and Neurosciences, University of Siena
Siena, Italy
University-Hospital S. Maria della Misericordia
Udine, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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