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Convergent Ablation Plus Left Atrial Appendage Isolation for the Treatment of Persistent Atrial Fibrillation

RecruitingNAAges 18 Years - 80 YearsAllBarts & The London NHS Trust
NCT06165510 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

A randomised controlled clinical trial to assess efficacy of convergent ablation with the LARIAT procedure, as compared to standard endocardial catheter ablation in patients with long-standing persistent atrial fibrillation (AF).

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age \> 18 years; \< 80 years * Persistent AF \> 1-year duration * Left atrium size \< 6cm * Pts should be able to provide written informed consent. Exclusion Criteria: * Subjects currently enrolled in another investigational study except in case of observational registry with no associated treatments. * Subject has a reversible cause of AF or transient AF * Subject is absent of LAA or if the LAA is previously surgically ligated * Subject has had previous cardiac surgery or abdominal surgery. * Subject has contraindication to anticoagulation. * Patients with hypertrophic cardiomyopathy. * Patients with significant valve disease. * Subject has had previous catheter or surgical ablation
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What it tests

  • Epicardial AF ablation using AtriCure EPi-Sense-AF Guided Coagulation System with Left Atrial Appendage Exclusion using the AtriCure LARIAT Suture Delivery Device.
  • Standard Endocardial Catheter Ablation
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Where

1 site
St Bartholomew's Hospital
London, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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