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POST URS Chemotherapy Instillation

RecruitingNAAges 18 Years - anyAllCarmel Medical Center
NCT06167057 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this study is to evaluate the safety and oncological outcomes of single chemotherapy bladder instillation following endoscopic treatment for UTUC in UTUC suspected patients .The main aim is to determine the efficacy of a single, post URS, chemotherapy bladder instillation to reduce IVR. Participants will be given single chemotherapy bladder instillation within 24h following ureteroscopy and will follow routine follow-up for IVR which will include white light cystoscopy ;patients with suspected IVR (based on either imaging or cystoscopy) will undergo TURBT.

Sign in to get the eligibility rules as simple questions to take to your doctor.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Radiographic and/or cytological suspicion for UTUC * Planned endoscopic procedure for treatment / diagnosis of UTUC * Patients with bladder cancer history are eligible if meeting both following criteria: No recurrence within the last two years Are not on active bladder irrigation protocol * Patients with history of UTUC are eligible if last endoscopic treatment or RNU was \>1 year prior to enrollment * Age ≥ 18 years * Performance status ECOG 0-2 Exclusion Criteria: * Subjects who have had bladder / prostate radiotherapy * Subjects with bladder cancer history on active bladder irrigation protocols or with active disease within two years prior to enrollment * Subjects with previously treated UTUC within one year prior to enrollment * Subjects with metastatic disease
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What it tests

  • Mitomycin/Gemcitabine
  • Saline
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Where

10 sites
Assuta Ashdod Hospital
Ashdod, Israel
Soroka University Medical Center
Beersheba, Israel
Shamir Medical Center
Be’er Ya‘aqov, Israel
Bnai Zion Medical Center
Haifa, Israel
Carmel Medical Center
Haifa, Israel
Rambam Health Care Campus
Haifa, Israel
Rabin Medical Center - Beilinson and Hasharon
Petah Tikva, Israel
Kaplan Medical Center
Rehovot, Israel

…and 2 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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