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Volatile Organic Compounds as Breath Biomarkers in Squamous Oesophageal Neoplasms

Recruitingn/aAges 18 Years - 90 YearsAllImperial College London
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In plain words

What the trial is, and whether it could suit you

Oesophageal Squamous Cell Carcinoma (OSCC) is a cancer of the food pipe that affects around 2000 patients in the UK every year. It is often detected at an advanced stage, resulting in poor survival (5-year survival less than 20%). Early detection can improve survival (5-year survival \>70%). Therefore, early detection is vital to improving survival. There are no national screening guidelines, and an endoscopy (A camera test to look at the food pipe) is the only available test to detect OSCC. Early detection of OSCC is challenging for many reasons. Firstly, early disease symptoms are non-specific, which patients often overlook. Secondly, 'Alarm' symptoms such as weight loss, difficulty swallowing or vomiting blood are signs of advanced stage. Lastly, endoscopy is an invasive test with associated risks and significant discomfort. The investigators propose to develop a breath test for pa

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: Participants with all the following characteristics will be eligible for inclusion in the study: 1. Cancer cohort (n=259): Patients with treatment naïve, histopathology confirmed OSCC. 2. Control cohort (n=259): Patients who have undergone or are undergoing an endoscopy (OGD) as part of their investigation for upper GI symptoms and are found to have either: * A normal upper gastrointestinal tract * Benign upper gastrointestinal disease Exclusion Criteria: Participants with the following characteristics will not be eligible for inclusion in the study: 1. Received some form of treatment (chemotherapy, radiotherapy, immunotherapy, endoscopic resection, or surgery) for OSCC 2. History of another cancer in the last five years 3. Non-squamous cell oesophageal cancer 4. Barrett's oesophagus (with or without dysplasia) 5. Previous oesophageal or gastric resection 6. Unable to provide written consent or lack capacity. 7. Pregnant women
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What it tests

  • Exhaled breath sampling
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Where

13 sites
Imperial College Healthcare NHS Trust
London, United Kingdom
Hull University Teaching Hospitals NHS Trust
Cottingham, United Kingdom
Cardiff and Vale University Health Board
Cardiff, United Kingdom
Velindre NHS Trust
Cardiff, United Kingdom
University Hospitals Coventry and Warwickshire NHS Trust
Coventry, United Kingdom
University Hospitals of Leicester NHS Foundation Trust
Leicester, United Kingdom
Liverpool University Hospitals NHS Foundation Trust
Liverpool, United Kingdom
The Clatterbridge Cancer Centre NHS Foundation Trust
Liverpool, United Kingdom

…and 5 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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