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Pola-R2 in Newly Diagnosed Non-fit Elderly DLBCL Patients

RecruitingPhase 2Ages 70 Years - anyAllYan Zhang, MD
NCT06176729 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a prospective, single-arm, phase II study, and the purpose of this study is to evaluate the efficacy and safety of Pola-R2 regimen in newly diagnosed elderly diffuse large B cell lymphoma classified into un-fit or frail group by comprehensive geriatric assessment(CGA).

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📋 Eligibility rules (as published)
Inclusion Criteria: * The patient volunteered to participate in the study and signed the Informed Consent * Histopathologically confirmed DLBCL and treatment naive(corticosteroids alone is not considered as a line of treatment) * Age≥ 70 years old, and was un-fit or frail according to comprehensive geriatric assessment * Adequate organ function and adequate bone marrow reserve Exclusion Criteria: * Coexisting malignancy other than lymphoma * Active HBV infection * Any instability of systemic disease, including but not limited to active infection (except local infection), severe cardiac, liver, kidney, or metabolic disease need therapy
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What it tests

  • Polatuzumab Vedotin, Rituximab, Lenalidomide
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Where

1 site
Peking Union Medical College Hospital
Beijing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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