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Advantages of Early Intrauterine Transfer of "Blank" Culture Medium Prior to 1st or 2nd Transfer of Thawed Embryo(s).

RecruitingNAAges any - anyFemaleCentre Hospitalier Universitaire de Nīmes
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In plain words

What the trial is, and whether it could suit you

Despite technical advances in Medically Assisted Reproduction (AMP), the success of fertility treatments is sometimes limited by embryo implantation failure. The coordinated development of the embryo and the uterine endometrium requires close communication between the maternal tissue and the embryo. In in vitro fertilization (IVF), embryo transfer generally takes place between the 2nd (D2) and the 6th (D6) day following oocyte fertilization. Recent studies have shown the advantages of sequential transfer (transfer of an embryo on D2/D3 followed by the transfer of another embryo on D5/D6), with higher implantation and clinical pregnancy rate, fewer miscarriages, more live births, and yet no increase in multiple pregnancies. However, the American Society for Reproductive Medicine recommendations continue to prioritize the transfer of a single embryo for all patients aged under 38. To impro

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📋 Eligibility rules (as published)
Inclusion Criteria: * Having had a first "fresh" or frozen embryo transfer, whatever the embryo's stage of development, transfer followed by pregnancy failure ; * Frozen embryos must be at least D3 stage; * The patient must have given their free and informed consent and signed the consent form * The patient must be a member or beneficiary of a health insurance plan Exclusion Criteria: * The subject is participating in an interventional study, or is in a period of exclusion determined by a previous study * The patient is under safeguard of justice or state guardianship
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What it tests

  • Blank culture transfer
  • Sham transfer
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Where

7 sites
Hôpital Antoine Béclère
Clamart, France
Centre Hospitalier Alpes Léman
Contamine-sur-Arve, France
CHU Arnaud de Villeneuve
Montpellier, France
Clinique Saint Roch
Montpellier, France
CHU de Nîmes
Nîmes, France
Clinique Saint-Pierre
Perpignan, France
CHU de la Réunion
Saint-Pierre, Reunion
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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