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White Matter Hyperintensities in Amnestic Mild Cognitive Impairment or Alzheimer's Disease

Recruitingn/aAges 65 Years - anyAllIRCCS Policlinico S. Donato
NCT06179680 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study focuses on assessing and measuring white matter hyperintensities in individuals with amnestic mild cognitive impairment (aMCI) or Alzheimer's disease. Objective: The primary objective of the study is to quantify the extent and distribution of white matter hyperintensities in the brains of individuals diagnosed with amnestic mild cognitive impairment or Alzheimer's disease. White matter hyperintensities are areas of increased signal intensity observed on brain magnetic resonance imaging (MRI) scans, often associated with various cognitive disorders. Importance: Understanding the presence and severity of white matter hyperintensities in individuals with aMCI or Alzheimer's disease is crucial for several reasons. These abnormalities may serve as potential biomarkers, aiding in the early diagnosis and prognosis of cognitive disorders. Additionally, quantifying white matter hyp

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📋 Eligibility rules (as published)
Inclusion Criteria: * Participants diagnosed with amnestic Mild Cognitive Impairment (aMCI) or Alzheimer's Disease (AD) based on clinical assessments. * Individuals undergoing brain magnetic resonance imaging (MRI) at the IRCCS Policlinico San Donato as part of routine diagnostic procedures. * Age-matched and gender-matched healthy control subjects for comparison. Exclusion Criteria: * Individuals with cognitive impairment other than amnestic MCI or AD. * History of significant neurological disorders (other than MCI or AD) that may impact the study outcomes. * Presence of contraindications for undergoing MRI procedures. * Any serious medical or psychiatric condition that, in the judgment of the researchers, may interfere with the study participation or compromise the validity of the results. * Known history of alcohol or substance abuse that may affect cognitive function. * Inability or unwillingness to provide informed consent.
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What it tests

  • Magnetic Resonance Imaging
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Where

1 site
IRCCS Policlinico San Donato
San Donato Milanese, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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