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Probiotics in Mild Alzheimer's Disease

RecruitingEARLY Phase 1Ages 65 Years - 85 YearsAllUniversity of Nicosia
NCT06181513 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The main objective is to investigate whether administration of probiotics to patients with mild Alzheimer's Disease (AD) reduces neuroinflammation, improves cognitive function and modifies neurophysiological measures, compared to a patient group that receives placebo (no active probiotics).

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults ≥65 years, able to give consent * Mini-Mental State Examination (MMSE) scores 19-23 (mild AD) * approximately equal male:female ratio Exclusion Criteria: * Inability to give consent * other neurological disease * relevant psychiatric disorders (e.g. major depression) * gastrointestinal/metabolic conditions * history of alcohol/substance dependence * use of systemic antibiotics in the previous 6 months * corticosteroid use * immune stimulating medications * immunosuppressive agents * probiotics consumption in the previous 6 months. * immunosuppression * structural heart disease * neutropenia * radiation * active intestinal disease
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What it tests

  • Probiotic Blend Capsule
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Where

1 site
The Cyprus Institute of Neurology and Genetics
Nicosia, Cyprus
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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