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Physical Activity and Fibrosing Interstitial Lung Disease

RecruitingNAAges 18 Years - anyAllAssistance Publique - Hôpitaux de Paris
NCT06182748 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Fibrotic interstitial lungs diseases (ILD) are a group of chronic and rare diseases characterized by an altered blood oxygenation in the lung, leading to dyspnea and physical limitation. Physical training is efficient to fight vicious circle of physical deconditioning observed in ILD. Eccentric cycling is an interesting modality of endurance training, allowing better exercise tolerance and adherence while developing cardiorespiratory function. Feasibility and efficacity of eccentric cycling were shown in chronic obstructive pulmonary disease but never in ILD. The primary aim of our work is to compare concentric and eccentric cycling training on physical capacities in ILD. Moreover, we will study the effects of training on the different steps of oxygen transport at exercise, from the lung to the muscles through the blood transport. Our second goal is then to characterize the physiological

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patient aged ≥ 18 years * Fibrosing PID with fibrosis score \> 10% of lung volume on chest CT scan * Be able to attend physical reconditioning 3 times a week * Be affiliated to a health insurance scheme * Sign informed consent form Exclusion Criteria: * Any contraindication to physical activity (hereafter, after Dany-Michel Marcadeta, Bruno Pavy et al. Recommendations of the French Society of Cardiology for stress tests 2018) * Be unable to perform exercise on an ergocycle or treadmill * Be unable to perform a stress test, particularly for people on long-term oxygen therapy rest oxygen therapy at home * IRS during an exacerbation * Change in treatment \< 3 months * Sarcoidosis * Connectivitis * Pregnancy in progress * Participation in a therapeutic intervention study * Patient under guardianship * Person subject to a legal protection measure * Patient on state medical aid
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What it tests

  • Training on eccentric ergocycle
  • Training on concentric ergocycle
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Where

1 site
Exercise and Sports Medicine Department
Bobigny, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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