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Effect of HF rTMS on Serum BDNF in Cocaine Use Disorder

RecruitingNAAges 18 Years - 50 YearsAllInstituto Nacional de Psiquiatría Dr. Ramón de la…
NCT06189690 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study aims to explore the effect of 5-Hz rTMS over the left dorsolateral prefrontal cortex on the BDNF, craving and cognitive function. This study will be longitudinal, with a short-term double-blind placebo-controlled phase consisting of 20 rTMS sessions and a long-term phase, consisting of 2 weekly sessions for 12 weeks. Participants will be clinically assessed pre-treatment (T0), after 20-sessions phase (T1) and after 12-weeks phase (T2) by an interview about psychiatric symptoms. Also, blood will be obtained in the same T0, T1 and T2 to peripheral levels of BDNF determination. Cognitive state will be measured at the same time-points (T0, T1, T2) by paper-pencil and computerized neuropsychological assessment. Researchers will compare active rTMS versus placebo 5 Hz-rTMS on described variables. Additionally, a comparative group (without rTMS intervention) will be included to equiv

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Current cocaine use disorder according to the Diagnostic and statistical manual of mental disorders (DSM 5). 2. Cocaine crack or powder use for at least 12 months with a frequency of 3 times or more per week, with abstinence periods shorter than 1 year for the last year. 3. Primary school completed. Exclusion Criteria: 1. Personal or first degree family history of any neurological disorder including, but not limited to, organic brain syndrome, epilepsy, brain injuries, multiple sclerosis, conditions that increase intracranial pressure. 2. Personal history of brain surgery or traumatic brain injury. 3. Comorbilities that could represent a risk of neuroinfection or increased convulsive threshoid. 4. Other than alcohol, tobacco or marijuana substance use disorder. 5. If the patient does not meet the safety criteria for rTMS. 6. Current use of any medication that might provoque seizures or any anticonvulsant drugs. 7. Personal history of schizophrenia, mania/hypomania or OCD. 8. Personal history of myocardial infarction, angina, congestive heart failure, cerebrovascular events, transient ischemic attack or any other heart condition currently undergoing medical treatment. 9. Personal history of seizures or detection of paroxysmal EEG activity.
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What it tests

  • rTMS
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Where

1 site
Instituto Nacional de Psiquiatría Ramón de la Fuente M.
Mexico City, Mexico
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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