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Vitamin D Treat-to-Target Strategy for Children With Overactive Bladder-Wet

RecruitingNAAges 5 Years - 18 YearsAllChildren's Hospital of Chongqing Medical Universi…
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In plain words

What the trial is, and whether it could suit you

The purpose of this clinical trial is to investigate whether adding high-dose vitamin D (2,400 IU daily) to standard medical treatment (solifenacin combined with behavioral therapy) is more effective than standard treatment alone for children with overactive bladder-wet (OAB-wet). OAB-wet causes sudden urinary urges and frequent daytime or incontinence, which significantly impacts a child's quality of life and increases the family's caregiving burden. While solifenacin is a standard medication used to calm the bladder, many children do not achieve complete dryness. This study introduces the "Treat-to-Target" (T2T) approach, where clinicians and families set personalized "functional goals" (such as zero leakage) and monitor progress closely to adjust care. The study aims to answer the following questions: Does adding vitamin D help more children achieve their goal of "zero leakage" com

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: * Children older than or equal to 5 years of age with a diagnosis of wet OAB (the diagnosis followed the latest guidelines of ICCS) attending the outpatient clinic of the Department of Urology of the Affiliated Children's Hospital of Chongqing Medical University, * children with serum vitamin D levels below 35 ng/ml as indicated by the tests conducted by the hospital * children whose guardians have given their informed consent, are able to ensure compliance and have signed a paper-based informed consent form. Exclusion Criteria: * Those with urinary malformations or serious diseases (e.g., hypospadias, cryptorchidism, posterior urethral valvulae, vesicoureteral reflux, neurogenic bladder, urinary tumors, urinary stones, bladder and urethral injuries, etc.) * Those with neurological disorders (e.g., epilepsy, spinal cord injuries, spinal dysplasia, spinal embolism syndrome, multiple sclerosis, and autism spectrum disorders, etc.) * People with serious heart disease, abnormal liver and kidney function, lung disease, bone deformity, serious digestive tract disease, genetic metabolic disease * People with history of gastrointestinal surgery and urological surgery * People with dry stools and long-term constipation * People who are taking anticonvulsant and antiepileptic drugs, hormones, and anti-tuberculosis drugs * People with history of hypercalcemia, hyperphosphatemia with renal rickets * People who have had unexplained hematuria and hematuria with renal rickets within the last year * People who have been suffering from severe heart disease or chronic diabetes. * participation in other clinical studies at the time of consultation or during the follow-up period of other clinical studies * unwillingness to participate in this study
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What it tests

  • urotherapy
  • Solifenacin Succinate
  • Vitamin D3
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Where

1 site
Children's Hospital of Chongqing Medical University
Chongqing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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